Prod P.Vermersch / L.Mars

 
Neuroinflammation and Multiple Sclerosis (NEMESIS).

Lanteri A, Sobanski V, Langlois C, Lefèvre G, Hauspie C, Sanges S, Lambert M, Morell-Dubois S, Hatron PY, Hachulla E, Launay D, Dubucquoi S. (2014) Serum free light chains of immunoglobulins as biomarkers for systemic sclerosis characteristics, activity and severity. Autoimmun Rev 13:974-980 (IF 7.9)

 

Lee-Chang C, Bodogai M, Moritoh K, Olkhanud PB, Chan AC, Croft M, Mattison JA, Holst PJ, Gress RE, Ferrucci L, Hakim F, Biragyn A. (2014) Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood. 28;124(9):1450-9.

 

Sobanski V, Dauchet L, Lefèvre G, Lambert M, Morell-Dubois S, Sy T, Hachulla E, Hatron PY, Launay D, Dubucquoi S. (2014) Prevalence of Anti-RNA Polymerase III Antibodies in Systemic Sclerosis: New Data From a French Cohort and a Systematic Review and Meta-Analysis. Arthritis Rheumatol 66:407-17 (IF 7.7)

 

Vermersch P, Czlonkowska A, Grimaldi LM, Confavreux C, Comi G, Kappos L, Olsson TP, Benamor M, Bauer D, Truffinet P, Church M, Miller AE, Wolinsky JS, Freedman MS, O’Connor P; TENERE Trial Group. (2014) Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial. Mult Scler. 20:705-16.

 

Outteryck O, Baille G, Hodel J, Giroux M, Lacour A, Honnorat J, Zéphir H, Vermersch P. (2013) Extensive myelitis associated with anti-NMDA receptor antibodies. BMC Neurol. 13:211.

 

Outteryck O, Zéphir H, Salleron J, Ongagna JC, Etxeberria A, Collongues N, Lacour A, Fleury MC, Blanc F, Giroux M, de Seze J, Vermersch P. (2013) JC-virus seroconversion in multiple sclerosis patients receiving natalizumab. Mult Scler.

 

Outteryck O, de Sèze J, Stojkovic T, Cuisset JM, Dobbelaere D, Delalande S, Lacour A, Cabaret M, Lepoutre AC, Deramecourt V, Zéphir H, Fowler B, Vermersch P. (2012) Methionine synthase deficiency: a rare cause of adult-onset leukoencephalopathy. Neurology. 79:386-8.

 

Mars LT, Saikali P, Liblau RS, Arbour N. (2011) Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models. Biochim Biophys Acta. 1812:151-61.

 

Lee-Chang C, Zéphir H, Top I, Dubucquoi S, Trauet J, Prin L, Vermersch P. (2011) B-cell subsets up-regulate α4 integrin and accumulate in the cerebrospinal fluid in clinically isolated syndrome suggestive of multiple sclerosis onset. Neurosci Lett. 487(3):273-7.

 

Lee-Chang C, Top I, Zéphir H, Dubucquoi S, Trauet J, Dussart P, Prin L, Vermersch P. (2011) Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis. Clin Immunol. 139:12-20.

 

Martin- Blondel G, Delobel P, Blancher A, Massip P, Marchou B, Liblau RS, and Mars LT. (2011) Pathogenesis of the immune reconstitution inflammatory syndrome affecting the central nervous system in patients infected with HIV. Brain. 134:928-46.

 

Mars LT, Araujo L, Kerschen P, Diem S, Bourgeois E, Van LP, Carrié N, Dy M, Liblau RS, Herbelin A. (2009) Invariant NKT cells inhibit development of the Th17 lineage. Proc Natl Acad Sci U S A. 106:6238-43.

 

Journiac N, Jolly S, Jarvis C, Gautheron V, Rogard M, Trembleau A, Blondeau JP, Mariani J, Vernet-der Garabedian B. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc Natl Acad Sci U S A. 106:21365-70.

 

Saxena A, Bauer J, Scheikl T, Zappulla J, Audebert M, Desbois S, Waisman A, Lassmann H, Liblau RS, and Mars LT. (2008) Cutting Edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. Journal of Immunology. 181:1617-21.

 

Lefèvre G, Meyer A, Launay D, Machelart I, DeBandt M, Michaud J, Tournadre A,Godmer P, Kahn JE, Behra-Marsac A, Timsit MA, Schleinitz N, Wendling D,Melac-Ducamp S, Boyer P, Peretz A, Lequerré T, Richez C, Stervinou-Wemeau L,Morell-Dubois S, Lambert M, Dubucquoi S, Wallaert B, Benveniste O, Flipo RM,Hatron PY, Sibilia J, Hachulla E, Hervier B; Club Rhumatismes, Inflammation. Seronegative polyarthritis revealing antisynthetase syndrome: a multicentre study of 40 patients. Rheumatology (Oxford). 2015 May;54(5):927-32. doi:10.1093/rheumatology/keu404. Epub 2014 Oct 27. PubMed PMID: 25349440.

 

Avril : Mihai C, Landewé R, van der Heijde D, Walker UA, Constantin PI, Gherghe AM,

Ionescu R, Rednic S, Allanore Y, Avouac J, Czirják L, Hachulla E, Riemekasten G,

Cozzi F, Airò P, Cutolo M, Mueller-Ladner U, Matucci-Cerinic M; EUSTAR

co-authors. Digital ulcers predict a worse disease course in patients with

systemic sclerosis. Ann Rheum Dis. 2016 Apr;75(4):681-6. doi:

10.1136/annrheumdis-2014-205897. Epub 2015 Feb 16. PubMed PMID: 25688073.

 

 

Février :

Lefèvre G, Copin MC, Roumier C, Aubert H, Avenel-Audran M, Grardel N, Poulain S, Staumont-Salle’ D, Seneschal J, Salles G, Ghomari K, Terriou L, Leclech C, Morati-Hafsaoui C, Morschhauser F, Lambotte O, Ackerman F, Trauet J, Geffroy S,Dumezy F, Capron M, Roche-Lestienne C, Taieb A, Hatron PY, Dubucquoi S, Hachulla E, Prin L, Labalette M, Launay D, Preudhomme C, Kahn JE. CD3-CD4+ lymphoid variant of hypereosinophilic syndrome: nodal and extranodal histopathological and immunophenotypic features of a peripheral indolent clonal T-cell lymphoproliferative disorder. Haematologica. 2015 Feb 14. pii:haematol.2014.118042. [Epub ahead of print] PubMed PMID: 25682606.

 

Janvier :

Hachulla E, Clerson P, Airò P, Cuomo G, Allanore Y, Caramaschi P, Rosato E,Carreira PE, Riccieri V, Sarraco M, Denton CP, Riemekasten G, Pozzi MR, Zeni S,Mihai CM, Ullman S, Distler O, Rednic S, Smith V, Walker UA, Matucci-Cerinic M,Müller-Ladner U, Launay D; on behalf of the EUSTAR co-workers. Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemicsclerosis EUSTAR population. Rheumatology (Oxford). 2015 Jan 17. pii: keu450.[Epub ahead of print] PubMed PMID: 25596413.

 

 

Publications 2014 :

Décembre :

 Trad S, Nosbaum A, Musset L, Ghillani-Dalbin P, Launay D, Costedoat-Chalumeau

N, Saadoun D, Cabane J, Hachulla E, Hanslik T, Frances C. Systemic sclerosis and prevalence of monoclonal immunoglobulin. Autoimmun Rev. 2014 Dec;13(12):1189-94. doi: 10.1016/j.autrev.2014.08.016. Epub 2014 Aug 23. PubMed PMID: 25151977.

 

 

Octobre :

Néel A, Henry B, Barbarot S, Masseau A, Perrin F, Bernier C, Kyndt X, Puechal X, Weiller PJ, Decaux O, Ninet J, Hot A, Aouba A, Astudillo L, Berthelot JM,Bonnet F, Brisseau JM, Cador B, Closs-Prophette F, Dejoie T, de Korwin JD, Dhote R, Fior R, Grosbois B, Hachulla E, Hatron PY, Jardel H, Launay D, Lorleac’h A,Pottier P, Moulis G, Serratrice J, Smail A, Hamidou M. Long-term effectivenessand safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler’ssyndrome: a French multicenter study. Autoimmun Rev. 2014 Oct;13(10):1035-41.doi: 10.1016/j.autrev.2014.08.031. Epub 2014 Aug 23. PubMed PMID: 25220180.

 

Launay D, Savale L, Berezne A, Le Pavec J, Hachulla E, Mouthon L, Sitbon O,Lambert B, Gaudric M, Jais X, Stephan F, Hatron PY, Lamblin N, Vignaux O, Cottin V, Farge D, Wallaert B, Guillevin L, Simonneau G, Mercier O, Fadel E, Dartevelle P, Humbert M, Mussot S; Working Group on Heart/Lung transplantation in systemicsclerosis of the French Network on Pulmonary Hypertension. Lung and heart-lungtransplantation for systemic sclerosis patients. A monocentric experience of 13patients, review of the literature and position paper of a multidisciplinaryWorking Group. Presse Med. 2014 Oct;43(10 Pt 2):e345-63. doi:

10.1016/j.lpm.2014.01.020. Epub 2014 Jul 11. Review. PubMed PMID: 25027464

 

12: Lefèvre G, Copin MC, Staumont-Sallé D, Avenel-Audran M, Aubert H, Taieb A,Salles G, Maisonneuve H, Ghomari K, Ackerman F, Legrand F, Baruchel A, Launay D, Terriou L, Leclech C, Khouatra C, Morati-Hafsaoui C, Labalette M, Borie R, CottonF, Gouellec NL, Morschhauser F, Trauet J, Roche-Lestienne C, Capron M, Hatron PY,Prin L, Kahn JE; French Eosinophil Network. The lymphoid variant ofhypereosinophilic syndrome: study of 21 patients with CD3-CD4+ aberrant T-cellphenotype. Medicine (Baltimore). 2014 Oct;93(17):255-66. doi:10.1097/MD.0000000000000088. PubMed PMID: 25398061. Elhai M, Avouac J, Walker UA, Matucci-Cerinic M, Riemekasten G, Airò P,Hachulla E, Valentini G, Carreira PE, Cozzi F, Balbir Gurman A, Braun-MoscoviciY, Damjanov N, Ananieva LP, Scorza R, Jimenez S, Busquets J, Li M, Müller-Ladner U, Kahan A, Distler O, Allanore Y; EUSTAR co-authors; EUSTAR co-authors. A gendergap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTARprospective study. Ann Rheum Dis. 2014 Oct 23. pii: annrheumdis-2014-206386. doi:10.1136/annrheumdis-2014-206386. [Epub ahead of print] PubMed PMID: 25342760

 

Septembre :

Lanteri A, Sobanski V, Langlois C, Lefèvre G, Hauspie C, Sanges S, Lambert M, Morell-Dubois S, Hatron PY, Hachulla E, Launay D, Dubucquoi S. Serum free lightchains of immunoglobulins as biomarkers for systemic sclerosis characteristics,activity and severity. Autoimmun Rev. 2014 Sep;13(9):974-80. doi:10.1016/j.autrev.2014.07.003. Epub 2014 Jul 25. PubMed PMID: 25067821.

 

Aout :

Avouac J, Walker UA, Hachulla E, Riemekasten G, Cuomo G, Carreira PE,Caramaschi P, Ananieva LP, Matucci-Cerinic M, Czirjak L, Denton C, Ladner UM,Allanore Y; the EUSTAR collaborators*; the EUSTAR collaborators. Joint and tendoninvolvement predict disease progression in systemic sclerosis: a EUSTARprospective study. Ann Rheum Dis. 2014 Aug 27. pii: annrheumdis-2014-205295. doi:10.1136/annrheumdis-2014-205295. [Epub ahead of print] PubMed PMID: 25165035. 

 

 

Juin :

van Laar JM, Farge D, Sont JK, Naraghi K, Marjanovic Z, Larghero J, SchuerweghAJ, Marijt EW, Vonk MC, Schattenberg AV, Matucci-Cerinic M, Voskuyl AE, van deLoosdrecht AA, Daikeler T, Kötter I, Schmalzing M, Martin T, Lioure B, Weiner SM,Kreuter A, Deligny C, Durand JM, Emery P, Machold KP, Sarrot-Reynauld F, Warnatz K, Adoue DF, Constans J, Tony HP, Del Papa N, Fassas A, Himsel A, Launay D, LoMonaco A, Philippe P, Quéré I, Rich É, Westhovens R, Griffiths B, Saccardi R, vanden Hoogen FH, Fibbe WE, Socié G, Gratwohl A, Tyndall A; EBMT/EULAR SclerodermaStudy Group. Autologous hematopoietic stem cell transplantation vs intravenouspulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomizedclinical trial. JAMA. 2014 Jun 25;311(24):2490-8. doi: 10.1001/jama.2014.6368.PubMed PMID: 25058083. Maurer B, Graf N, Michel BA, Müller-Ladner U, Czirják L, Denton CP, Tyndall A,Metzig C, Lanius V, Khanna D, Distler O; EUSTAR co-authors. Prediction ofworsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database. Ann Rheum Dis. 2014 Jun 30. pii:annrheumdis-2014-205226. doi: 10.1136/annrheumdis-2014-205226. [Epub ahead ofprint] PubMed PMID: 24981642. Terrier B, Marie I, Launay D, Lacraz A, Belenotti P, de Saint-Martin L,Quemeneur T, Huart A, Bonnet F, Le Guenno G, Kahn JE, Hinschberger O, Rullier P, Diot E, Lazaro E, Bridoux F, Zénone T, Carrat F, Hermine O, Léger JM, Mariette X,Senet P, Plaisier E, Cacoub P. Predictors of early relapse in patients withnon-infectious mixed cryoglobulinemia vasculitis: results from the Frenchnationwide CryoVas survey. Autoimmun Rev. 2014 Jun;13(6):630-4. doi:10.1016/j.autrev.2013.11.006. Epub 2014 Jan 10. Review. PubMed PMID: 24418300. Heusele M, Clerson P, Guery B, Lambert M, Launay D, Lefevre G, Morell-Dubois S, Maillard H, Le Gouellec N, Hatron PY, Hachulla E. Risk factors for severebacterial infections in patients with systemic autoimmune diseases receivingrituximab. Clin Rheumatol. 2014 Jun;33(6):799-805. doi:10.1007/s10067-014-2509-2. Epub 2014 Feb 2. PubMed PMID: 24487486; PubMed CentralPMCID: PMC4058071. 

 

Février :

Sobanski V, Dauchet L, Lefèvre G, Lambert M, Morell-Dubois S, Sy T, HachullaE, Hatron PY, Launay D, Dubucquoi S. Prevalence of anti-RNA polymerase IIIantibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis. Arthritis Rheumatol. 2014 Feb;66(2):407-17. doi:10.1002/art.38219. Review. PubMed PMID: 24504813.

 

Janvier :

Mekinian A, Braun T, Decaux O, Falgarone G, Toussirot E, Raffray L, Omouri M,Gombert B, De Wazieres B, Buchdaul AL, Ziza JM, Launay D, Denis G, Madaule S,Rose C, Grignano E, Fenaux P, Fain O; Club Rhumatismes et Inflammation (CRI),Groupe Francophone des Myélodysplasies (GFM); Société Nationale Française deMédecine Interne (SNFMI). Inflammatory arthritis in patients with myelodysplasticsyndromes: a multicenter retrospective study and literature review of 68 cases.Medicine (Baltimore). 2014 Jan;93(1):1-10. doi: 10.1097/MD.0000000000000011.Review. PubMed PMID: 24378738.

 

 

Publications 2013 :

Décembre :

Novembre :

Hervier B, Meyer A, Dieval C, Uzunhan Y, Devilliers H, Launay D, Canuet M,Têtu L, Agard C, Sibilia J, Hamidou M, Amoura Z, Nunes H, Benveniste O, GrenierP, Montani D, Hachulla E. Pulmonary hypertension in antisynthetase syndrome:prevalence, aetiology and survival. Eur Respir J. 2013 Nov;42(5):1271-82. doi:

10.1183/09031936.00156312. Epub 2013 Feb 8. PubMed PMID: 23397301

Octobre :

Sivova N, Launay D, Wémeau-Stervinou L, De Groote P, Remy-Jardin M, Denis G, Lambert M, Lamblin N, Morell-Dubois S, Fertin M, Lefevre G, Sobanski V, Le RouzicO, Hatron PY, Wallaert B, Hachulla E, Perez T. Relevance of partitioning DLCO to detect pulmonary hypertension in systemic sclerosis. PLoS One. 2013 Oct18;8(10):e78001. doi: 10.1371/journal.pone.0078001. eCollection 2013. PubMedPMID: 24205063; PubMed Central PMCID: PMC3799734. 

 

Septembre :

Lefèvre G, Dauchet L, Hachulla E, Montani D, Sobanski V, Lambert M, HatronPY, Humbert M, Launay D. Survival and prognostic factors in systemicsclerosis-associated pulmonary hypertension: a systematic review andmeta-analysis. Arthritis Rheum. 2013 Sep;65(9):2412-23. doi: 10.1002/art.38029.Review. PubMed PMID: 23740572.

 

Mars :

Launay D, Dutoit-Lefevre V, Faure E, Robineau O, Hauspie C, Sobanski V,Hachulla E, Labalette M, Hatron PY, Dubucquoi S. Effect of in vitro and in vivoanakinra on cytokines production in Schnitzler syndrome. PLoS One.2013;8(3):e59327. doi: 10.1371/journal.pone.0059327. Epub 2013 Mar 19. PubMed

PMID: 23527164; PubMed Central PMCID: PMC3602040

 

Guillevin L, Hunsche E, Denton CP, Krieg T, Schwierin B, Rosenberg D,Matucci-Cerinic M; DUO Registry Group. Functional impairment of systemicscleroderma patients with digital ulcerations: results from the DUO Registry.Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):71-80. Epub 2013 Jul 22. PubMedPMID: 23910613.