Neuroinflammation and Multiple Sclerosis (NEMESIS) and Fibrosis And Immunity Research Group
Lennart Mars Patrick Vermersch
T and B lymphocytes are the cellular components of the adaptive immune response. Their functional plasticity and the expression of hypervariable antigen receptors endow lymphocytes with a central role in immunity. Distinct differentiation programs ensure that these white blood cells optimise their molecular armamentory to eliminate infections and eradicate cancer. This critical effector arm is balanced by regulatory lymphocytes able to restrain the immune response during health. Our team is dedicated to the understanding and therapy of autoimmune inflammatory diseases, which arise when the homeostasis of the adaptive immune system is compromised. Our translational research explores the cellular and molecular mechanisms of disease.
Our Team builds on three structural elements. We are located in the LIRIC research center that we joined since its creation in 2015. Our research activity benefits from our association with the clinical departments of neurology (MS-clinic headed by Pr Patrick Vermersch), internal medicine (Headed by Pr Eric Hachulla), and hematology (Pr I Yakoub-Agha). This provides the foundation for active translational and clinical research that is further facilitated due to the contribution of the clinical immunology institute (headed by Pr Myriam Labalette). The mixture of basic scientists and physician scientists improves the training, multidisciplinarity and ultimately quality of both biologists and clinicians that have been trained within our environment.
Neuroinflammation and Multiple Sclerosis (NEMESIS).
Brain inflammation can be particularly harmful due to the poor regenerative capacity of neurons and glial cells. We investigate the pathophysiology and treatment of brain inflammation with a particular interest in Multiple Sclerosis. Voir plus
Fibrosis and Immunity Research Group (FIRE)
Fibrosis is the final common outcome of many autoimmune and inflammatory diseases. We investigate the role of the immune system in fibrogenesis in this context with a particular interest in systemic sclerosis and graft versus host disease.Voir plus